Journal vol.7 no.1 abstract5 of The Japan Health Care Dental Association

The Journal of The Japan Health Care Dental Association Vol.7 No.1, 2005
abstract

Yoshiaki Nomura, DDS, Ichiro Saito, DDS, PhD

Cortisol and Chromogranin A(CgA) in saliva are regarded as biochemical markers of emotional stress. 741 saliva samples collected from the patients who visited the dental offices were measured the amount of the substance to specify the normal range of them in salvia of healthy individuals. Assuming that the normal range includes 95% of the measured distribution, the normal range of Chromogranin A is 0-46pmol/ml. Subsequently, other study was conducted in Tsurumi University Dental Hospital to examine if such measured can be of value as a maker of clinical diagnosis. The saliva samples collected from the outpatients who presented the symptom of the dry mouth but were not identified the etiology of dry mouth (presumably associated with emotional stress) were measured the amount of Cortisol and Chromogranin A. And, with matching the age and gender, both measurand of Cortisol and Chromogranin A in the two studies were compared. In consequence, the patients with dry mouth have substantially higher values especially for Chromogranin A.